UCSF

Tagged: Research

Research: Elusive drug targets; cell demolition enzymes; useful pharmacogenomics info

Predicting difficult-to-detect drug binding sites

Most drugs are comprised of small molecules that pass through cell membranes and are designed to bind to much larger protein molecules at exposed concave pockets. But in many disease-associated proteins, these binding sites are difficult to detect. Concave pockets may form only in the immediate presence of small molecules that bind to them (natural ligands or drugs) or are open only for brief periods during protein shape-shifting.

Chemical cocktail induces fibroblasts to become heart cells

C&EN: Chemical & Engineering News

Research: pediatric meningitis dosing; cancer drug resistance; gene-testing economics

Computer models provide optimal dosing for pediatric TB meningitis

Big stem cell news: dynamic duo of all-chemical direct reprogramming reports

The Niche: Knoepfler Lab stem cell blog

Chemicals used to turn skin cells into heart and brain cells

In a major breakthrough, scientists at the Gladstone Institutes, led by UCSF School of Pharmacy faculty member Sheng Ding, PhD, have transformed skin cells into heart and brain cells using combinations of chemicals.

All previous work on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat. The research lays the groundwork for potentially being able to regenerate lost or damaged cells via pharmaceuticals.

On being quoted in the NYT, Preprints, and Beer (and Tacos)

News from the Fraser Lab

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